The Sixers, who have been idle since Saturday’s 118-104 win over the Detroit Pistons, lead the second-place Brooklyn Nets by three games.
Indiana, which trails the eighth-place Charlotte Hornets by one game, can secure a berth in the play-in tournament with a win and a Bulls’ loss.
Philadelphia has won both games against Indiana this season, most recently defeating the Pacers 130-114 at home on March 1.
If the Sixers are to sweep the season series, they may have to do so without Joel Embiid, who was listed as questionable on the NBA’s injury report with an illness unrelated to COVID-19. Sabonis missed six games recently due to a lower back issue.