The Sixers open the regular season against the New Orleans Pelicans on Wednesday.
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The 25-year-old Simmons, a three-time All-Star, met with Sixers coach Doc Rivers on Tuesday.
Sixers president Daryl Morey and Rivers have been publicly optimistic since the start of training camp that Simmons would play again for the Sixers.
Simmons has averaged 15.9 points, 8.1 rebounds and 7.7 assists over four seasons with the Sixers.